Can you recover from a diabetic stroke

Diabetes mellitus (DM) is recognized as an important risk factor for stroke and might theoretically influence post-stroke level of disability, increasing the extension of the cerebral injured area. However, results of the few researches aimed at studying this influence are contradictory; moreover, the effect of DM on motor recovery has not been extensively studied. The aim of this study was to investigate the effect of DM on both functional and motor recovery.

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Methods

A total of 395 acute patients with first stroke were selected in a rehabilitation department and divided into two groups on the basis of the presence or absence of DM (DM+ and DM−, respectively). Outcome measures were the Barthel Index, the Fugl-Meyer Assessment Scale, and the mobility part of the motor assessment chart according to Lindmark and Hamrin. Participants were assessed at admission to department (T1, 13.9±7.9 days from stroke onset), at discharge (T2, 40.1±13.4), and at follow-up (T3, 84.2±14.3). A 2×3 analysis of variance with repeated measures was performed to verify the effect of group and of phase of assessment on motor and functional measures and their interaction.

Results

DM+ and DM− groups included 93 and 302 patients, respectively. Both groups showed a significant and progressive improvement in all outcome measures (P<.001), but no interaction was found between group and phase of assessment, which means that motor and functional recovery was similar in the two groups.

Conclusion

Results suggest that diabetes has no influence on motor and functional outcome within the acute and post-acute phase after stroke. Further research should investigate motor recovery in a longer-term period and with larger samples.

Introduction

Diabetes mellitus (DM) represents a strong independent risk factor for stroke (Bell, 1994, Goldstein et al., 2001, Stegmayr and Asplund, 1995). Generally, it has been associated with ischemic stroke (Folsom et al., 1999, Gorelick, 2002), while its association with hemorrhagic stroke is not clear (Mankowsky & Ziegler, 2004).

Diabetic patients have higher association with other cardiovascular risk factors such as hypertension, hyperlipidemia, obesity, and insulin resistance, which make the metabolic syndrome (Magliano, Shaw, & Zimmer, 2006).

While the full entity of metabolic syndrome was associated with the higher risk of stroke (Najarian et al., 2006), the association between any of the individual components of metabolic syndrome and the specific risk of stroke in persons with metabolic syndrome is uncertain (Isomaa et al., 2001).

Some authors showed a correlation between history of diabetes and mortality (Hamidon and Raymond, 2003, Jorgensen et al., 1994) and morbidity (Toto, 2005), probably due to microangiopathy (Kawai et al., 1998). However, other authors did not find differences between patients with and without diabetes in terms of mortality 1 year after ischemic stroke (Kissela et al., 2005).

DM may influence the post-stroke clinical evolution, especially in the initial phase, increasing the extension of the cerebral injured area (Siemkowicz & Gjedde, 1980), but, at the moment, there is no full accordance on the association of hyperglycemia in the acute stage of stroke with mortality and neurological recovery (Colagiuri et al., 2002, Mankovsky et al., 1996). In fact, the correlation between stroke type, lesion sites, and outcome in diabetics is still not clear Karapanayiotides et al., 2004).

Few studies have been aimed at studying the influence of diabetes on functional outcomes after stroke, and their results are not conclusive (Pulsinelli et al., 1983, Toni et al., 1992). Moreover, recovery has been assessed only in terms of disability (Karapanayiotides et al., 2004, Megherbi et al., 2003) or handicap (Megherbi et al., 2003), which can be influenced by comorbidity (Gainotti, Antonucci, Marra, & Paolucci, 2001) or social factors (Gilbertson et al., 2000). For these reasons, scales for motor impairment should be included in the assessment of recovery.

The aim of this study was to estimate the influence of DM on functional and motor recovery from stroke.

Section snippets

Setting

The study was performed in the Department of Rehabilitation Medicine of a city hospital, which is the only one serving a territory of 365 km2 with a population, at the start of the study, of 224,392 (source: Istituto Nazionale di Statistica, Census 1997). Patients coming from the other departments of the same hospital with indication of motor rehabilitation are selected by department physicians, according to the clinical indication of rehabilitation, the level of disability, and the clinical

Results

A total of 395 patients finished the study, after 23 participants (6 with diabetes) withdrew from the study because of changes in their personal circumstances and 19 others pulled out (4 with diabetes) because of serious health problems. DM was diagnosed in 93 patients (23.5%). Therefore, the DM+ group and the DM− group included 93 patients (age, 74.4±6.3) and 302 patients (age, 71.6±7.3), respectively. Table 1 compares gender and age distribution and patients' general clinical characteristics,

Discussion

For many years, DM has been shown to be an independent risk factor for stroke, especially for ischemic stroke (Bell, 1994, Stegmayr and Asplund, 1995). However, investigations about the influence of the DM on functional recovery after stroke have been undertaken only recently. Our results show no differences between the DM− and the DM+ groups in terms of severity of hemiplegia at baseline and in all the outcome measures at each assessment session. Some previous studies reported similar results (

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      What happens when a diabetic has a stroke?

      Diabetes increases the chance of having a stroke, which can damage brain tissue and cause disability or even death. To prevent stroke, people with diabetes should control blood glucose, blood pressure, cholesterol and weight.

      What are the signs of a diabetic stroke?

      Symptoms.
      Sudden numbness or weakness in the face, arm, or leg (especially on one side of the body).
      Trouble speaking or understanding words or simple sentences..
      Sudden blurred vision or worse vision in one or both eyes..
      Sudden trouble swallowing..
      Dizziness, loss of balance, or lack of coordination..

      How high does your sugar have to be to have a stroke?

      Elevated blood glucose is common in the early phase of stroke. The prevalence of hyperglycemia, defined as blood glucose level >6.0 mmol/L (108 mg/dL), has been observed in two thirds of all ischemic stroke subtypes on admission and in at least 50% in each subtype including lacunar strokes.

      Can you recover from diabetic shock?

      With prompt treatment, a rapid recovery is possible. However, without early treatment, it can be fatal or result in brain damage. It can happen to a person with type 1 or type 2 diabetes.